Random forest classifier trained on sequence features and functional data to uncover small proteins in Mycobacterium tuberculosis.

Multiple non-canonical DNA structures exist at the BCL6 cluster II breakpoint region and contribute to the fragility leading to BCL6 translocation in DLBCL patients.

This work explores epigenetic signalling during epithelial to mesenchymal transition in colorectal cancer cells with varying status of p53.

In search of antivirals against Dengue, drug repurposing studies have been made using 4 non structural viral protein domains as drug targets. Our studies indicate that the drug compounds tolcapone, cefprozil, delavirdine and indinavir can be potential therapeutic compounds against Dengue infections.

This pilot study investigates the circulating tumor cells (CTCs) in oral squamous cell carcinoma (OSCC) patients, offering insights for early diagnosis and prognosis through minimally invasive liquid biopsy.

Protein domains are crucial for determining protein functionality, serving as structural and functional units essential for diverse biological processes. This study delves into the intricate world of the structures of these domains, focuses on the strength of interactions within two-domain proteins and compares strong (permanent) and weak (transient) interations. The results provide better understanding of multi-domain protein structure, function and folding principles

This study hi2ghlights curcumin’s role as an epigenetic modulator in ovarian cancers. Curcumin modulated distinct miRNA regulatory networks to induce cellular cytotoxicities in two different ovarian cancer cell lines (PA1 and A2780) underscoring its cell-type-specific mode of action.

This study tested the activity of an HSP90 inhibitor, SP11, against leukemic cells, mouse lymphoma allograft, and xenograft models.

3Biosensors are a powerful tool for real-time high-throughput screening. In this study,  a synthetic biosensor based on the AraC-pBAD system was  designed and constructed for the detection of isoprene.

14This systematic review compiles sporadic literature on Aconitum spp, regarding its nomenclature and classification, endangerment, plant morphology, ploidy, secondary metabolites, drug pharmacokinetics, conservation, and omics-based computational studies.

Naturally occurring small molecules have been identified as inhibitors for TRAM, an innate immunity protein, through bioinformatics studies, followed by cell reporter assays and NMR experiments

Fusion transcript detection led to the discovery of novel complex karyotypes specific to the Indian Acute Leukemia population

1Multi-omics analysis uncovered population-specific novel variants in tumour-specific contexts such as possible drivers, miRNAs and alternative splicing events in the Indian cohort.

This study reports construction and functional validation of new plasmids useful for achieving robust transcriptional upregulation of genes in Aedes cells, thus allowing implementation of the CRISPR activation system in mosquitoes.

Specific functions among the genes consistently down-regulated in the testes of men with NonObstructive Azoospermia, after removing well known spermatogenic genes.

The lower abundance of intrinsic terminators, high cellular levels of Rho, and its genome-wide association with a majority of transcriptionally active genes indicate the predominant role of Rho-mediated termination in Mycobacterium tuberculosis.

This study uses a multi-omics approach to understand the global gene expression and metabolite changes induced by Disarib, a novel Bcl2-specific inhibitor in the Ehrlich adenocarcinoma (EAC) breast cancer mouse model and shows that Disarib reduces tumours by reducing oncometabolite and activating apoptosis and downregulating angiogenesis.

Transcriptome data of Moringa concanensis Nimmo (MC) and M. oleifera (MO) have been compared. They are well-known for their abundance of molecules with medicinal properties. In terms of molecular abundance of secondary metabolites, expression of enzymes in the biosynthesis pathway and in vitro glucosidase inhibitory activity, the leaves of MC score higher.

The TNF-TNFR system has been conserved since before the vertebrate-invertebrate split some 700 million years ago with evidence of Eiger (TNF homolog) gene present as far back as porifera.

Quantitative knowledge of metabolism can help in rationalized engineering of micro-organisms for increasing product synthesis. In this paper we carry out 13C based metabolic flux analysis to gain insight into the metabolism of isoprene-producing cyanobacteria.

We proposed easy-to-adapt phylum names against the recently changed names proposed by the International Committee on Systematics of Prokaryotes (ICSP).

Most primer/probe-designing tools are inefficient in designing junction primers and are reported without experimental validation. We report a better software after thorough experimentally validation.

A database that contains information regarding regulatory information on RAG1 and RAG2 in normal and aberrant B and T cells from mice and humans.

NGS data analysis and differential co-expression network analysis show altered regulation of glycolysis genes in the circulating CD8+ T cells of Rheumatoid arthritis patients

All countries must increase sequencing efficiency and submit SARS-CoV-2 genomes to open access platforms rapidly to keep up with the emergence of newer variants.

Actin-binding protein  regulates G1-to-S phase transition and mitotic  spindle orientation during cell division cycle of a protozoan organism, Leishmania donovani.

We report the genome assembly of IndCh (Chennai, India) strain of An. stephensi, which is found to be homozygous for the standard form of the 2Rb chromosome configuration (2R+^b/2R+^b), allowing us to extract segregating SNP signatures and the identification of candidate genes responsible for the expansion range of this important malaria vector in India.

Curcumin is well known for its anticancer properties. Its cytotoxic activity has been documented in several cancer cell lines, including breast cancer. With the help of integrative analysis we have shown regulation of biomarker miRNAs and mRNAs pairs mediated by Curcumin.

Differentially regulated genes across multiple cancers were systematically integrated using bipartite graph principles. Further analyses of these graphs resulted in protein functional interactions, which are likely important for cancer specific functions.

This study provides a comprehensive transcriptional analysis of the Myxococcus xanthus developmental cycle while comparing it with the vegetative biofilms grown in rich and poor nutrients. It portrays several differentially expressed genes involved in key central metabolic pathways suggesting their role in regulating myxobacterial development.

This study analyzes the median ‘strain collection to genome submission time lag’ per country for 1.7 million SARS-CoV-2 strains. It recommends an effective SARS-CoV-2 genomic surveillance system focusing on increasing the sequencing potential and rapid genome submission to open access platforms like GISAID.

As part of our studies of drug discovery against SARS-CoV-2, we carried out in silico studies using 637 phytochemicals from spices and condiments used in the Indian Diet, against the viral helicase and one of human immune regularoty proteins.

Progressive atrophic rhinitis in domestic pigs is caused by Pasteurella multocida strains containing toxA, which encodes a heat-labile toxin. Here, by comparative analyses of the genomes of many strains, it has been shown that toxA is sparsely distributed in P. multocida. Also, toxA is usually associated with a prophage, and some strains contain an orthologous prophage but not toxA.

It is essential to register each clinical trial, providing complete and accurate data, in a timely fashion. We have quantified the widely divergent quality of 18 major public clinical trial registries, and have defined features of an interim ideal one.

The Methicillin-Resistant Staphylococcus aureus (MRSA) strain LVP-7 was isolated in India a few years ago. Here, we present its draft genome and identify key features that could explain its virulence properties. We are currently improving genome assembly using long-read sequencing and analyzing the transcriptome of this MRSA strain

Glutathione peroxidase 3 in various cancers, and its use as a prognostic biomarker and a potential target for clinical intervention.

The bovine (and ovine) opportunistic pathogen Histophilus somni contains luxS and forms a biofilm.
luxS mutant compared to that in the wild-type, whether the bacteria were grown planktonically or in a biofilm.

Transcriptomic meta-analysis of expression pattern among smoking lung cancer patients identified 9 gender-biased genes, consistent across at least 4 studies.

The use of protein–protein interaction networks to unravel the mechanism of action of Curcuma longa L bioactives.

A chromosome-level genome assembly of the first malaria vector from India reveals genes within an inversion locus linked to insecticide resistance.

Active at nanomolar concentrations, ST09 can potentially be developed as a novel antitumor drug candidate for highly metastatic and aggressive breast cancer.

A novel moving-window based approach using RNA-Seq data was developed to detect context-dependent expression of small RNAs in M. tuberculosis.

10s or 100s of regulatory trials that have run in India appear not to have been registered with Clinical Trials Registry-India (CTRI), as required by the law.

Whole-genome and pan-genome analysis of 167 SARS-CoV-2, 312 SARS-CoV, and 5 Pangolin CoV isolates to understand the diversity and evolution of Coronaviruses

Systematic, multi-omic data analysis in M. smegmatis highlighted significant expression and translation signals in the pseudogene regions, calling for the re-annotation of bacterial pseudogenes.

Profilin regulates intracellular transport in Leishmania.

Myosin 21, a novel form of myosin with two UBA-like domains in its tail region, regulates flagellum assembly, intracellular vesicle transport and cell motility in Leishmania promastigotes.

By comparing the crt loci, the carotenogenesis pathway, and the possible origins of two strains of Sphingomonas echinoides, have been proposed.

Arbitrary selection of bioinformatic resources hurts science. Our results help objective choice of ‘protein-protein interaction’ databases/tools.

Combined genomic and functional network analyses were performed to predict biofilm and quorum-sensing associated proteins in M. tuberculosis.

Green synthesis of silver nanoparticles (ST06-AgNPs) using curcumin derivative (ST06) on EAC tumor bearing mice models

Various deficiencies in the data of interventional drug trials registered with Clinical Trials Registry – India were identified.

Phylogenetic analysis using 16S rDNA and deduced proteome sequences facilitated the identification of several novel species of the genus Chryseobacterium.

Superposition of crystal structures of the arsenic responsive regulatory protein – ArsR, in complex with trivalent arsenic ion, from a couple of microbial species.

Effects of rheumatoid arthritis associated transcriptional changes on osteoclast differentiation network in the synovium

A novel molecular mechanism for a long non-coding RNA PCAT92 implicated in prostate cancer