The primary focus of our lab is to develop a quantitative model of Natural Killer (NK) cell effector function. NK cells integrate signals from a diverse set of activating and inhibitory receptors that they express on their cell surface. A sophisticated balance between activating and inhibitory signaling determines their effector function. The mechanism that governs this balance is not well understood. We use mathematical methods seeded in ordinary differential equations (ODE), partial differential equations (PDE), and Statistical inference and computer simulation to construct mechanistic models of NK cell effector functions. Our models seek to integrate available experiments and make falsifiable predictions.
We are also interested in uncovering general strategies that organisms can follow to maximize their respective fitness over a long period of time. The bet-hedging strategy of maintaining phenotypic diversity is well known in this context. Keeping bet-hedging strategy aside we ask if anticipation can confer long-term fitness to organisms and if it is a robust strategy. We are working on developing a broad theory of anticipation.
Institute of Bioinformatics & Applied Biotechnology
Biotech Park, Electronic City Phase I
Bengaluru 560100, Karnataka
- Michael Dworkin, Sayak Mukherjee, Ciriyam Jayaprakash and Jayajit Das, “ Dramatic reduction of dimensionality in large biochemical networks owing to strong pair correlations” Journal of the Royal Society Interface, Vol 9 no 73, page 1824-1835, August 2012.
- Sayak Mukherjee, Jing Zhu, Julie Zikherman, Ramya Parameswaran, Theresa A. Kadlecek, Qi Wang, Byron Au-Yeung, Hidde Ploegh, John Kuriyan, Jayajit Das, Arthur Weiss, “Monovalent and Multivalent Ligation of the B Cell Receptor Exhibit Differential Dependence upon Syk and Src Family Kinases”, Science Signaling, Vol 6, Issue 256, January 2013.
- Sayak Mukherjee, Sang-Cheol Seok, Veronica J. Vieland, and Jayajit Das, “Cell responses only partially shape cell-to-cell variations in protein abundances in Escherichia coli chemotaxis.” Proc Natl Acad Sci, Vol 110, no.46, pp 18531-18536, November 12, 2013.
- Luise Westernberg, Claire Conche, Yina Hsing Huang, Stephanie Rigaud, Yisong Deng, Sabine Siegemund, Sayak Mukherjee, Lyn’Al Nosaka, Jayajit Das, Karsten Sauer, “Non-canonical antagonism of PI3K by the kinase Itpkb delays thymocyte b-selection and renders it Notch-dependent”. eLife, 5: e10786. DOI: 10.7554/eLife.10786, 2016.
- Sayak Mukherjee, Helle Jensen, William Stewart, David Stewart, William C. Ray, Shih-Yu Chen, Garry P. Nolan, Lewis L. Lanier, and Jayajit Das, “In silico modeling identifies CD45 as a regulator of IL-2 synergy in the NKG2D-mediated activation of immature human NK cells”, Science Signaling, Vol. 10, Issue 485, eaai9062, 2017.
- Mukherjee, S. and Saberwal, G. Managing India’s AIDS crisis in the 2000s: Quantitative modeling had impact. Current Science, (Guest Editorial) (in press)
Ms. Aishwarya Iyenger (Research Assistant)
Mr. D. Arjun (student)
Mr. D. SasiKumar (currently moved to the corporate sector)
Dr. R. Srivatsan (IBAB, India)
Dr. G. Saberwal (IBAB, India)
Dr. Pallab Basu (ICTS, India)
Dr. Jayajit Das (NCH, USA)
Dr. Salim Khakoo (University of South Hampton)
Dr. Bernice Mbiribindi (Stanford University, USA)